Author

Eric Julien

Centre National de la Recherche ScientifiqueORCID 0000-0003-2976-666XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:ChIP-seq· 3 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Cyril RibeyreiD· 2 shared David LlèresiD· 2 shared Fatima AlhouraniiD· 2 shared Florence M. CammasiD· 2 shared Julie PatouillardiD· 2 shared Véronique BaldiniD· 2 shared Adeline TorroiD· 1 shared Aurélie GennetieriD· 1 shared

Activity by Year

2018-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Cyril RibeyreORCID

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4 papers

Recent·Most cited

Cell BiologybioRxivPreprintAug 18, 2026

Isotype specific loss of HP1α but not of HP1β uncovers genomic regions that behave as HP1α-dependent common fragile sites

Karen Yaacoub, Thành Nhân Nguyễn, Eric Julien, Florence M. Cammas

The paper shows that loss of HP1α, but not HP1β, increases chromosomal breaks and fragile site activity under replication stress.

DOI 10.64898/2026.08.14.744815

humanDNA methylation

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Cancer BiologybioRxivPreprintMar 11, 2025

Targeting SUV4-20H epigenetic enzymes as therapeutic strategy for enhancing topoisomerase II poisoning in prostate cancer

Fatima Alhourani, Marine Tauziet, Julie Patouillard…·Eric Julien

This study shows that inhibiting SUV4-20H enzymes enhances the effectiveness of TOP2 poisons in prostate cancer by increasing DNA damage and impairing repair mechanisms.

DOI 10.1101/2025.03.11.642623

humanbulk RNA-seq

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Molecular BiologyCell CyclePeer-reviewedFeb 16, 2025

Cell-cycle dependent inhibition of BRCA1 signaling by the lysine methyltransferase SET8

Yannick Perez, Fatima Alhourani, Julie Patouillard…·Eric Julien

This study shows SET8 inhibits BRCA1 signaling during S-phase by promoting 53BP1 accumulation, and its degradation is essential for BRCA1 and RAD51 complex nuclear focal accumulation.

2 citations

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Molecular BiologyNature CommunicationsPeer-reviewedSep 6, 2018

A histone H4K20 methylation-mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing

Muhammad Shoaib, David Walter, Peter J. Gillespie…·Claus Storgaard Sørensen

The paper identifies a chromatin compaction threshold mediated by histone H4K20 methylation that limits DNA replication licensing in G1 phase to maintain genome integrity.

92 citationstop 3%

humanDNA methylation

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