Mads Lerdrup

Pulsed-SILAC in single mouse embryos reveals early embryonic protein synthesis dynamics and phosphosite regulation

The paper uses pulsed-SILAC in single mouse embryos to study protein synthesis dynamics and phosphosite regulation during early embryogenesis, revealing active maternal proteome synthesis and post-translational regulation.

Major waves of H2A.Z incorporation during mouse oogenesis

The paper maps H2A.Z incorporation during mouse oogenesis, identifying distinct patterns and their relationship with epigenetic marks and transposable elements.

N6-Methyladenosine Safeguards Mouse and Human Germline Competence

This study shows that reducing N6-methyladenosine (m6A) levels in mouse and human pluripotent cells disrupts germline entry by altering signaling pathways, chromatin states, and gene expression.

Sex-Specific DNA-Replication In The Early Mammalian Embryo

The paper investigates DNA replication timing in mouse zygotes and 2-cell embryos, revealing an asynchronous replication program in 2-cell embryos that differs from embryonic stem cells.

N6-methyladenosine dynamics during early vertebrate embryogenesis

This study examines m6A dynamics during early vertebrate embryogenesis, finding increased m6A in polyadenylated mRNA and its association with translational efficiency and RNA degradation.

A histone H4K20 methylation-mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing

The paper identifies a chromatin compaction threshold mediated by histone H4K20 methylation that limits DNA replication licensing in G1 phase to maintain genome integrity.