Author
Cancer Research HorizonsORCID 0000-0003-4363-0339Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Nikhil Gupta, Andy Sayer, Malwina Prater…·Alex Kalinka
This study compares CRISPR knockout and interference methods using single-cell RNA sequencing to evaluate their strengths in functional genomics.
Curtis Hart, Lovely Jael Paul Solomon Devakumar, Khalid Saeed…·Nikhil Gupta
The paper develops a scarless conditional sgRNA system using endogenous RNA processing to enable precise temporal control of genome editing with improved efficiency and fidelity.
Sebastian Łukasiak, Alex T. Kalinka, Nikhil Gupta…·David Walter
The paper benchmarks CRISPR sgRNA design algorithms and creates smaller, efficient libraries for loss-of-function screens.
Matthew A. Clarke, Charlie George Barker, Ashley Nicholls…·Jasmin Fisher
This paper develops an in silico model to predict personalized therapeutic combinations for NSCLC by simulating genetic profiles and testing drug combinations to overcome resistance.
Muhammad Shoaib, David Walter, Peter J. Gillespie…·Claus Storgaard Sørensen
The paper identifies a chromatin compaction threshold mediated by histone H4K20 methylation that limits DNA replication licensing in G1 phase to maintain genome integrity.