MYC-induced oncogenesis is dependent on acidic patches within its N-terminal intrinsically disordered domain.
Víctor Llombart, David O’Connor, Jonas Demeulemeester, Amandeep Bhamra, Silvia Šurinová, Adam Turňa, Kent T.M. Fung, Lingyi Wang, Yang Li, Tanya Rapoz-D’Silva, Farah Ahmed, Henri Niskanen, Ida Stöppelkamp, Denes Hnisz, Sandro Bottaro, , Marc R. Mansour
This study identifies acidic patches in the MYC N-terminal disordered domain essential for oncogenesis and chromatin interaction, offering new therapeutic targets.
bioRxiv · Jun 16, 2025 · PreprintCancer Biology