A Promising Chemical Series of Positive Allosteric Modulators of the μ-Opioid Receptor that Enhance the Antinociceptive Efficacy of Opioids but not their Adverse Effects
Kerri D. Pryce, Hye Jin Kang, Farhana Sakloth, Yongfeng Liu, Susan Khan, Katalin Tóth, Abhijeet Kapoor, Andrew Nicolais, Tao Che, Lihuai Qin, Féodora L. Bertherat, H. Ümit Kanıskan, Jian Jun Jin, Michael D. Cameron, Bryan L. Roth, , Marta Filizola
The paper characterizes two MOR PAMs that enhance opioid antinociception without increasing adverse effects in mouse models.
Neuropharmacology · Jun 18, 2021Peer-reviewedNeuroscience