SCOPE: Revealing Hidden Mechanisms in Phenotypic Screens Through Target and Pathway Enrichment
Abhijeet Kapoor, Keith J. Kelleher, Suzanne M. Underhill, Sankalp Jain, Brandon K. Harvey, Mark J. Henderson
SCOPE identifies molecular mechanisms in phenotypic screens by linking compound data to pathways and targets, revealing calcium signaling and HRH1 as key in exodosis regulation.
bioRxiv · Jul 11, 2025 · PreprintBioinformatics