HIV infection in microglia leads to senescence, triggering activation of neurotoxicity pathways
Sara J. Mason, Sheetal Sreeram, Farshad Niazi, Konstantin Leskov, Alan D. Levine, Jonathan Karn, Saba Valadkhan
This study shows HIV infection in microglia induces cellular senescence similar to normal aging, with p53 pathway activation and inflammatory gene upregulation, suggesting senescence pathways as therapeutic targets for HAND.
bioRxiv · May 8, 2025 · PreprintMicrobiology