Author

Sheetal Sreeram

Case Western Reserve UniversityORCID 0000-0001-8031-9617Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Jonathan KarniD· 2 shared Konstantin LeskoviD· 2 shared Alan D. LevineiD· 1 shared Anthony J. Wynshaw-BorisiD· 1 shared Asha R. KallianpuriD· 1 shared Benjamin G. LuttgeiD· 1 shared Farshad Niazi· 1 shared Fengchun YeiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

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10 top collaborators · 33 mutual co-author links

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2 shared papersMicrobiology

Jonathan KarnORCID

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintAug 10, 2026

Transcriptional Mapping of Neuro-Immune Interactions during Homeostasis and HIV infection using Microglia-containing Human Cerebral Assembloids

Sheetal Sreeram, 陈雅, Luke A. D. Bury…·Jonathan Karn

This study uses microglia-containing human cerebral assembloids to analyze neuroimmune interactions during homeostasis and HIV infection, revealing microglial reactivity and neuroprotective responses.

DOI 10.64898/2026.08.10.743763

humanscRNA-seq

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MicrobiologybioRxivPreprintMay 8, 2025

HIV infection in microglia leads to senescence, triggering activation of neurotoxicity pathways

Sara J. Mason, Sheetal Sreeram, Farshad Niazi…·Saba Valadkhan

This study shows HIV infection in microglia induces cellular senescence similar to normal aging, with p53 pathway activation and inflammatory gene upregulation, suggesting senescence pathways as therapeutic targets for HAND.

2 citations

humanbulk RNA-seq

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