Author

Konstantin Leskov

Case Western Reserve UniversityORCID 0000-0001-6201-5660Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:scRNA-seq· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1

Frequent Co-Authors

Jonathan KarniD· 3 shared Saba ValadkhaniD· 2 shared Sheetal SreeramiD· 2 shared Alan D. LevineiD· 1 shared Anthony J. Wynshaw-BorisiD· 1 shared Asha R. KallianpuriD· 1 shared Benjamin G. LuttgeiD· 1 shared Farshad Niazi· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersMicrobiology

Jonathan KarnORCID

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintAug 10, 2026

Transcriptional Mapping of Neuro-Immune Interactions during Homeostasis and HIV infection using Microglia-containing Human Cerebral Assembloids

Sheetal Sreeram, 陈雅, Luke A. D. Bury…·Jonathan Karn

This study uses microglia-containing human cerebral assembloids to analyze neuroimmune interactions during homeostasis and HIV infection, revealing microglial reactivity and neuroprotective responses.

DOI 10.64898/2026.08.10.743763

humanscRNA-seq

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MicrobiologybioRxivPreprintMay 8, 2025

HIV infection in microglia leads to senescence, triggering activation of neurotoxicity pathways

Sara J. Mason, Sheetal Sreeram, Farshad Niazi…·Saba Valadkhan

This study shows HIV infection in microglia induces cellular senescence similar to normal aging, with p53 pathway activation and inflammatory gene upregulation, suggesting senescence pathways as therapeutic targets for HAND.

2 citations

humanbulk RNA-seq

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Molecular BiologyPLoS PathogensPeer-reviewedSep 16, 2021

Biogenesis of P-TEFb in CD4+ T cells to reverse HIV latency is mediated by protein kinase C (PKC)-independent signaling pathways

Uri R. Mbonye, Konstantin Leskov, Meenakshi Shukla…·Jonathan Karn

This study identifies PKC-independent signaling pathways that reactivate HIV latency by regulating P-TEFb availability in CD4+ T cells.

26 citations

humanbulk RNA-seq

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