Saba Valadkhan

Preventing Microglial Reactivity Protects from Acute and Progressive Neuronal Dysfunction, Motor Impairments and Sedation following Alcohol Abuse

This study shows that preventing microglial reactivity protects against acute and progressive neurological dysfunction and motor impairments caused by alcohol abuse in mice.

HIV infection in microglia leads to senescence, triggering activation of neurotoxicity pathways

This study shows HIV infection in microglia induces cellular senescence similar to normal aging, with p53 pathway activation and inflammatory gene upregulation, suggesting senescence pathways as therapeutic targets for HAND.

Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress

The paper shows that cells use an adaptive pausing response to survive severe stress by pausing translation and limiting ATP use, followed by recovery through ISR signaling.

Biogenesis of P-TEFb in CD4+ T cells to reverse HIV latency is mediated by protein kinase C (PKC)-independent signaling pathways

This study identifies PKC-independent signaling pathways that reactivate HIV latency by regulating P-TEFb availability in CD4+ T cells.