Jonathan Karn

This study uses microglia-containing human cerebral assembloids to analyze neuroimmune interactions during homeostasis and HIV infection, revealing microglial reactivity and neuroprotective responses.

This study shows HIV infection in microglia induces cellular senescence similar to normal aging, with p53 pathway activation and inflammatory gene upregulation, suggesting senescence pathways as therapeutic targets for HAND.

This study identifies PKC-independent signaling pathways that reactivate HIV latency by regulating P-TEFb availability in CD4+ T cells.