Mitochondrial citrate carrier SLC25A1 is a dosage-dependent regulator of metabolic reprogramming and morphogenesis in the developing heart
Chiemela Ohanele, Jessica N. Peoples, Anja Karlstaedt, Joshua T. Geiger, Ashley D. Gayle, Nasab Ghazal, Fateemaa Sohani, Milton E. Brown, Michael E. Davis, George Arthur Porter Jr., Victor Faúndez, Jennifer Q. Kwong
This study identifies SLC25A1 as a dosage-dependent regulator of metabolic reprogramming and heart development, linking mitochondrial function to cardiac morphogenesis and congenital heart disease.
bioRxiv · May 22, 2023 · PreprintDevelopmental Biology