TGFb induced embryonic cell senescence at the origin of the Cornelia de Lange syndrome
Céline Hachoud, Faten Chaabani, Erwan Watrin, Manuela Wuelling, Heiko Peters, Valérie Cormier‐Daire, Michel Pucéat
This study identifies TGFβ pathway dysregulation and cell senescence as key factors in CdLS mouse model, showing that inhibiting TGFβR prevents cardiac and growth defects.
bioRxiv · Jul 26, 2022 · PreprintDevelopmental Biology