Erwan Watrin

TDG orchestrates ATF4-dependent gene transcription during retinoic acid-induced cell fate acquisition

The paper investigates TDG's role in cell differentiation by showing its involvement in ATF4-dependent gene transcription during retinoic acid-induced neural fate commitment.

Aurora-A phosphorylates splicing factors and regulates alternative splicing

This study identifies Aurora-A as a splicing kinase that regulates alternative splicing by phosphorylating splicing factors and altering RNA motifs in affected regions.

The histone methyltransferase NSD3 contributes to sister chromatid cohesion and to cohesin loading during mitotic exit

This study identifies NSD3 as a regulator of cohesin loading during mitotic exit, showing its interaction with kollerin and its role in sister chromatid cohesion.

TGFb induced embryonic cell senescence at the origin of the Cornelia de Lange syndrome

This study identifies TGFβ pathway dysregulation and cell senescence as key factors in CdLS mouse model, showing that inhibiting TGFβR prevents cardiac and growth defects.

MAU2 and NIPBL variants in Cornelia de Lange syndrome reveal MAU2-independent loading of cohesin and uncover a protective mechanism against early truncating mutations in NIPBL

The paper investigates variants in MAU2 and NIPBL in CdLS, showing NIPBL haploinsufficiency as the main cause and revealing a protective mechanism for NIPBL out-of-frame mutations.