Michel Pucéat

This study shows that LSD1 inhibitors reduce cardiac fibrosis and improve ventricular function in both mouse and pig models of ischemic and congenital heart diseases.

The study identifies miR-106a-3p as a regulator of adult stem/progenitor cell fate through transcriptional control in 3D cultures.

The paper identifies the origin, fate, and clonal contribution of endocardial progenitors to the development of the cardiac mitral valve using single-cell RNA sequencing and genetic tracing in mice.

This study identifies TGFβ pathway dysregulation and cell senescence as key factors in CdLS mouse model, showing that inhibiting TGFβR prevents cardiac and growth defects.

The paper shows that cardiac macrophages in pigs with right ventricular failure drive cardiomyocyte de-differentiation and regeneration through epimorphosis.

SCHNAPPs is a Shiny-based tool for bench-scientists to analyze scRNA-seq data, offering quality control, clustering, differential expression, and visualization with reproducible reporting.

This study shows maternal vitamin D deficiency causes heart defects in offspring by altering 3D-chromatin structure and gene regulation across generations.

This study investigates the role of Hoxb1 in regulating cardiac progenitor cell patterning and differentiation, showing its negative regulation of posterior SHF differentiation and its impact on congenital heart defects.

This paper develops a human pluripotent stem cell model to study valvulogenesis and disease, showing it can recapitulate valve development and disease traits like mitral valve prolapse.

This study shows that geometric cues can direct the self-patterning of Brachyury-positive cells in embryonic stem cell aggregates without relying on morphogen gradients.