Atypical memory B cells contribute to heterogeneous vaccine responses in ocrelizumab-treated patients with multiple sclerosis
Ryan Curtin, Yogambigai Velmurugu, Fatoumatta Dibba, Hao Yuan, Chaitra Sreenivasaiah, Alireza Khodadadi‐Jamayran, Samantha Nyovanie, Angie H. Kim, Marie I. Samanovic, Mark J. Mulligan, Jessica Priest, Mark S. Cabatingan, Ryan C. Winger, Y. Patskovsky, Ilya Kister, , Michelle Krogsgaard
The paper examines how B-cell subsets in ocrelizumab-treated multiple sclerosis patients influence vaccine responses to SARS-CoV-2, identifying specific B-cell populations associated with immune response variability.
bioRxiv · Nov 3, 2025 · PreprintImmunology