Mutant p53 Directs PARP to Regulate Replication Stress and Drive Breast Cancer Metastasis
Gu Xiao, George K. Annor, Katherine W. Harmon, Valery A. Chavez, Fayola A. Levine, Samuel Terkper Ahuno, Mohamed I. Atmane, Samantha C. St. Jean, Florencia P. Madorsky Rowdo, Pamella Leybengrub, Annmarie Gaglio, Viola Ellison, Divya Venkatesh, Siyu Sun, Taha Merghoub, , Jill Bargonetti
This study shows mutant p53 uses its C-terminal domain to reprogram PARP activity, enabling replication stress adaptation and metastasis in TNBC, and identifies mtp53 as a biomarker for PARP inhibitor and DNA-damaging therapy.
bioRxiv · Mar 28, 2026 · PreprintCancer Biology