Mutant p53 Directs PARP to Regulate Replication Stress and Drive Breast Cancer Metastasis
Gu Xiao, George K. Annor, Katherine W. Harmon…·Jill Bargonetti
This study shows mutant p53 uses its C-terminal domain to reprogram PARP activity, enabling replication stress adaptation and metastasis in TNBC, and identifies mtp53 as a biomarker for PARP inhibitor and DNA-damaging therapy.