Author

Siyu Sun

Memorial Sloan Kettering Cancer CenterORCID 0000-0001-8461-9609Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genetics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Benjamin D. GreenbaumiD· 2 shared Alexander SolovyoviD· 1 shared Amir Hosseini· 1 shared Anastasia BaryshnikovaiD· 1 shared Andrea Di GioacchinoiD· 1 shared Annmarie GaglioiD· 1 shared Bao-Han LyiD· 1 shared Daniel Diniz De CarvalhoiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

Benjamin D. GreenbaumORCID

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3 papers

Recent·Most cited

Mutant p53 Directs PARP to Regulate Replication Stress and Drive Breast Cancer Metastasis

Gu Xiao, George K. Annor, Katherine W. Harmon, Valery A. Chavez, Fayola A. Levine, Samuel Terkper Ahuno, Mohamed I. Atmane, Samantha C. St. Jean, Florencia P. Madorsky Rowdo, Pamella Leybengrub, Annmarie Gaglio, Viola Ellison, Divya Venkatesh, Siyu Sun, Taha Merghoub, , Jill Bargonetti

This study shows mutant p53 uses its C-terminal domain to reprogram PARP activity, enabling replication stress adaptation and metastasis in TNBC, and identifies mtp53 as a biomarker for PARP inhibitor and DNA-damaging therapy.

bioRxiv · Mar 28, 2026 · PreprintCancer Biology

Repeats Mimic Pathogen-Associated Patterns Across a Vast Evolutionary Landscape

Petr Šulc, Andrea Di Gioacchino, Alexander Solovyov, Siyu Sun, Stephen Martis, Sajid A. Marhon, Håvard T. Lindholm, Raymond Chen, Amir Hosseini, Hua Liang Jiang, Bao-Han Ly, Martin S. Taylor, Parinaz Mehdipour, Omar Ibrahim Abdel-Wahab, Nicole Rusk, , Benjamin D. Greenbaum

The paper quantifies viral mimicry in genomes across species and shows how repetitive elements maintain pathogen-like features under selection.

Cell Genomics · Sep 25, 2025Peer-reviewedSystems Biology

Regulatory kinase genetic interaction profiles differ between environmental conditions and cellular states

Siyu Sun, Anastasia Baryshnikova, Nathan J. Brandt, David Gresham

The paper identifies differences in genetic interaction profiles of regulatory kinases between proliferative and quiescent yeast cells under various nutrient conditions.

Molecular Systems Biology · May 1, 2020Peer-reviewedGenetics