Immune Checkpoint Therapy Drives Maturation of a Cellular Neighborhood Nucleated by T Cell-APC Triads Enabling Spatially Compartmentalized Tumor Immunity
Ruan F.V. Medrano, Vladimir Sukhov, Kevin Hoffer-Hawlik, Bar Rozenman, Cora D. Arthur, Fei Han, Bassem Ben Cheikh, Hussein Sultan, Yoshiko Takeuchi, Samuel Ameh, Derek J. Theisen, Yuang Song, Heather N. Kohlmiller, J. Michael White, Alexey Sergushichev, , Robert D. Schreiber
The paper uses multiplex imaging to track the development of T cell-APC triad neighborhoods during immune checkpoint therapy, showing their role in spatially organizing tumor immunity.
bioRxiv · Apr 12, 2026 · PreprintImmunology