Kevin Hoffer-Hawlik

ARCADIA integrates scRNA-seq and spatial proteomics to reveal spatially dependent transcriptional programs without cell barcode pairing or feature-level correspondence.

The paper uses multiplex imaging to track the development of T cell-APC triad neighborhoods during immune checkpoint therapy, showing their role in spatially organizing tumor immunity.

The paper identifies co-expression patterns of chemokine receptors on CD8+ T cells that distinguish anti-tumor efficacy from off-target toxicity in melanoma.

Echidna quantifies gene dosage effects on phenotypic plasticity by integrating scRNA-seq and WGS data to separate genetic from cell non-autonomous mechanisms.