Alexey Sergushichev

The paper uses multiplex imaging to track the development of T cell-APC triad neighborhoods during immune checkpoint therapy, showing their role in spatially organizing tumor immunity.

This study identifies O-GlcNAcylation and reduced glycolysis as key factors in Th2 polarization by dendritic cells, showing their role in immune synapse regulation and TCR signaling.

The paper identifies CR1 variants as a risk factor for FSGS across diverse populations through a case-control study and variant analysis.

Phantasus is a web-application that provides interactive gene expression analysis and access to over 84000 public datasets, enabling users to perform analysis from data loading to differential expression.

The paper analyzes genetic and phenotypic data from 4,145 Russians to explore ethnic diversity and genetic associations, finding enrichment of Finnish-specific variants and providing a GWAS database.

GCDPipe ranks risk genes, cell types, and drugs for complex traits using GWAS and expression data, showing effectiveness in disease applications.

FGSEA estimates preranked GSEA P-values down to 10^-100 with predictable error in seconds to minutes, recovering more FDR-significant pathways across 605 GEO datasets than the Broad implementation.

The paper introduces a soft vertex classification method for identifying active modules in biological networks, providing confidence estimates and FDR control.