Directed evolution of multimeric proteins is enabled by dual-compensatory gene duplication
Rezwan Siddiquee, Felicia Lie, Taylor N. Szyszka, Alex Loustau, Michael P. Andreas, Tobias W. Giessen, Yu Heng Lau
This paper introduces a directed evolution strategy for multimeric proteins using gene duplication to enable the selection of diverse high-performing variants.
bioRxiv · Jan 12, 2026 · PreprintEvolutionary Biology