Yu Heng Lau

This paper introduces a directed evolution strategy for multimeric proteins using gene duplication to enable the selection of diverse high-performing variants.

This paper describes an in vitro method for packaging synthetic cargo into encapsulin protein cages with high fidelity and broad compatibility, outperforming in cellulo assembly.

The paper shows that a single point mutation in a virus-like capsid can drive the formation of tetrahedral structures instead of the typical icosahedral symmetry.

This study investigates how pore structure affects stability and molecular flux in engineered protein cages through design, structural analysis, and simulations.

The paper demonstrates an artificial nanocompartment in yeast that enhances metabolic pathway efficiency by stabilizing enzymes and reducing toxicity.

This paper demonstrates the use of prokaryotic encapsulins to create synthetic organelles in yeast, enabling compartmentalization of proteins and enzymatic activity.

This paper introduces a method for rapid genome recoding in Salmonella typhimurium by iteratively recombineering synthetic DNA, achieving the highest number of codon substitutions in a single organism.