A Versatile Anti-CRISPR Platform for Opto- and Chemogenetic Control of CRISPR-Cas9 and Cas12 across a Wide Range of Orthologs
Luca Brenker, Sabine Aschenbrenner, Felix Bubeck, Kaloyan Staykov, Carolin Gebhardt, Benedict Wolf, Michael Jendrusch, Ann-Sophie Kröll, Jan Mathony, Dominik Niopek
This paper develops a versatile platform for optogenetic and chemogenetic control of CRISPR-Cas9 and Cas12 across multiple orthologs using engineered anti-CRISPR proteins.
bioRxiv · Nov 25, 2024 · PreprintSynthetic Biology