C19 trityl and silyl andrographolide analogs exhibit in vitro anticancer activity in murine cancer models
Rushika Raval, Ruirui Liu, Aileen Pak, Abigail K. Yee, Srinidhi Venkatesh, Lutecia Lam, Alisha Hothi, Lavernie Chen, Allyson Yu, Hailey Seto, Claudia Casal Montserrat, Feng Wang-Johanning, Gary L. Johanning, Edward Njoo
This study evaluates trityl and silyl ether analogs of andrographolide in murine cancer cell lines, finding potent anticancer activity and mechanisms involving apoptosis and Wnt1/β-catenin signaling.
bioRxiv · Oct 30, 2026 · PreprintCancer Biology