Lack of neuroprotection after systemic administration of the soluble TNF inhibitor XPro1595 in an rAAV6-α-Syn+PFFs-induced rat model for Parkinson's disease
Filip Fredlund, Claes Fryklund, Olivia Trujeque-Ramos, Hannah A. Staley, Joaquín Pardo, Kelvin C. Luk, Malú G. Tansey, Maria Swanberg
This study shows that systemic XPro1595, a TNF inhibitor, does not protect against -Syn-induced Parkinson's-like pathology in rats, despite being effective in other neurodegeneration models.
Neurobiology of Disease · Feb 13, 2025Peer-reviewedNeuroscience