APOE3 Christchurch modulates tau phosphorylation and regulates β-catenin/Wnt/Cadherin signaling in induced pluripotent stem cell-derived cerebral organoids from Alzheimer's cases
Randall C. Mazzarino, Paula Andrea Perez-Corredor, Timothy E. Vanderleest, Guido N. Vacano, Justin S. Sanchez, Nelson David Villalba‐Moreno, S Krausemann, MA Mendivil-Perez, David Fernando Aguillon, Marlene Jiménez-Del-Río, Ana Y. Baena, Diego Sepúlveda Falla, FJ Lopera, Yakeel T. Quiroz, Joseph F. Arboleda‐Velásquez
This study shows that the APOE3Ch variant reduces tau phosphorylation and regulates Wnt/Cadherin signaling in cerebral organoids from Alzheimer's cases, suggesting a protective mechanism against tauopathy.
bioRxiv · Jan 11, 2023 · PreprintNeuroscience