Author

Diego Sepúlveda Falla

University Medical Center Hamburg-EppendorfORCID 0000-0003-0176-2042Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:mouse· 2 Assay:proteomics· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2

Frequent Co-Authors

Markus GlatzeliD· 3 shared Nelson David Villalba‐Moreno· 3 shared Susanne KrasemanniD· 3 shared Andrés VillegasiD· 2 shared David Fernando AguilloniD· 2 shared Duvan Cardona‐Madrigal· 2 shared Joseph F. Arboleda‐VelásqueziD· 2 shared Mohsin ShafiqiD· 2 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersNeuroscience

Markus GlatzelORCID

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4 papers

Recent·Most cited

NeurosciencebioRxivPreprintAug 7, 2026

Mechanisms of resilience to autosomal dominant Alzheimer's disease via oligogenic modulation of rare variants in the entorhinal cortex

Yassir El‐Amri, Nelson David Villalba‐Moreno, Julia Urban…·Diego Sepúlveda Falla

DOI 10.64898/2026.08.03.742644

𝕏 PostBluesky

NeurosciencebioRxivPreprintJul 22, 2026

Astrocyte-driven small vessel disease is an early, amyloid-independent feature of PSEN1 E280A familial Alzheimer's disease

Jessica Lisa Villalba-Moreno, Yassir El‐Amri, K I Kim…·Diego Sepúlveda Falla

The paper identifies astrocyte-driven small vessel disease as an early, amyloid-independent feature of PSEN1 E280A familial Alzheimer's disease through proteomic and transcriptomic analyses.

DOI 10.64898/2026.07.17.739026

𝕏 PostBluesky

NeuroscienceActa NeuropathologicaPeer-reviewedJul 9, 2024

Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases

Feizhi Song, Valerija Kovač, Behnam Mohammadi…·Hermann C. Altmeppen

This study identifies ADAM10-mediated shedding of human PrP at Y226 and shows sPrP associates with misfolded protein aggregates in neurodegenerative diseases.

9 citations

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NeurosciencebioRxivPreprintJan 11, 2023

APOE3 Christchurch modulates tau phosphorylation and regulates β-catenin/Wnt/Cadherin signaling in induced pluripotent stem cell-derived cerebral organoids from Alzheimer's cases

Randall C. Mazzarino, Paula Andrea Perez-Corredor, Timothy E. Vanderleest…·Joseph F. Arboleda‐Velásquez

This study shows that the APOE3Ch variant reduces tau phosphorylation and regulates Wnt/Cadherin signaling in cerebral organoids from Alzheimer's cases, suggesting a protective mechanism against tauopathy.

7 citations

humanexperimental assay

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