Lysosomal escape and TMEM106B fibrillar core determine TDP-43 seeding outcomes
Weijia Zhong, Carlo Scialò, Beatrice Gatta, Manon Anic Haefliger, Noemi Leu, Flavio Lurati, M Peter, Nandini Ramesh, Bernd Roschitzki, Somanath Jagannath, Ruchi Manglunia, Elena De Cecco, Su Min Lim, Oscar G. Wilkins, Adriano Aguzzi, , Magdalini Polymenidou
The paper investigates factors determining TDP-43 seeding outcomes in FTLD-TDP, identifying TMEM106B fibrillar core and lysosomal escape as critical drivers.
bioRxiv · Dec 22, 2025 · PreprintNeuroscience