NeurosciencebioRxivPreprint
Lysosomal escape and TMEM106B fibrillar core determine TDP-43 seeding outcomes
Weijia Zhong, Carlo Scialò, Beatrice Gatta…·Magdalini Polymenidou
The paper investigates factors determining TDP-43 seeding outcomes in FTLD-TDP, identifying TMEM106B fibrillar core and lysosomal escape as critical drivers.
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