Inhibitor-induced supercharging of kinase turnover via endogenous proteolytic circuits
Natalie S. Scholes, Martino Bertoni, Arnau Comajuncosa-Creus, Katharina Kladnik, Xuefei Guo, Fabian Frommelt, Matthias Hinterndorfer, Hlib Razumkov, Polina Prokofeva, Martin P. Schwalm, Florian Born, Sandra Röhm, Hana Imrichová, Brianda L. Santini, Eleonora Barone, , Georg E. Winter
The paper identifies inhibitor-induced kinase destabilization as a common phenomenon and reveals that it occurs through endogenous proteolytic mechanisms rather than classical ubiquitination.
Nature · Nov 26, 2025Peer-reviewedMolecular Biology