Scalable intracellular delivery via microfluidic vortex shedding enhances the function of chimeric antigen receptor T-cells
Brandon J. Sytsma, Vincent Allain, Struan Bourke, Fairuz Faizee, Mohsen Fathi, Leonardo M. R. Ferreira, W. Jared Brewer, Lian Li, Fong L. Pan, Allison G. Rothrock, William A. Nyberg, Zhongmei Li, Leah H. Wilson, Rebecca Berdeaux, Justin Eyquem, Ryan S. Pawell
This study introduces hydroporation as a scalable and efficient method for delivering CAR-T cells, achieving higher yields and viability compared to traditional methods.
Scientific Reports · Feb 17, 2025Peer-reviewedBioengineering