Inhibition of nucleotide synthesis promotes replicative senescence of human mammary epithelial cells
Alireza Delfarah, Sydney Parrish, Jason A. Junge, Jesse Yang, Frances Seo, Si Li, John Mac, Pin Wang, Scott E. Fraser, Nicholas Alexander Graham
This study shows that inhibiting nucleotide synthesis induces replicative senescence in human mammary epithelial cells by blocking metabolic flux into nucleotide pathways.
Journal of Biological Chemistry · May 28, 2019Peer-reviewedSystems Biology