Sydney Parrish

In situ, High-Resolution Quantification of CO2 Uptake Rates via Automated Off-Gas Analysis Illuminates Carbon Uptake Dynamics in Cyanobacterial Cultures

This paper develops a low-cost system for high-resolution CO2 uptake rate measurement in cyanobacterial cultures and shows that uptake rates increase linearly then decay to cessation.

AKT but not MYC promotes reactive oxygen species-mediated cell death in oxidative culture

The paper shows that AKT, but not MYC, causes cell death in oxidative conditions by increasing reactive oxygen species, revealing a metabolic vulnerability in cancer cells.

NADPH consumption by L-cystine reduction creates a metabolic vulnerability upon glucose deprivation

The paper identifies L-cystine reduction as a metabolic vulnerability in cancer cells under glucose deprivation and proposes co-targeting GLUT1 and glutathione synthesis as a therapeutic strategy.

Inhibition of nucleotide synthesis promotes replicative senescence of human mammary epithelial cells

This study shows that inhibiting nucleotide synthesis induces replicative senescence in human mammary epithelial cells by blocking metabolic flux into nucleotide pathways.