Alireza Delfarah

Drug mechanism enrichment analysis improves prioritization of therapeutics for repurposing

This paper introduces DMEA, a method that improves drug repurposing by grouping drugs with shared mechanisms of action, enhancing prioritization and reducing off-target effects.

Elucidating Tumor-stromal Metabolic Crosstalk in Colorectal Cancer through Integration of Constraint-Based Models and LC-MS Metabolomics

This study investigates tumor-stromal metabolic interactions in colorectal cancer by integrating constraint-based models with metabolomics data, revealing how cancer-associated fibroblasts reprogram tumor cell metabolism.

Identification of a Proteomic Signature of Senescence in Primary Human Mammary Epithelial Cells

The paper identifies a proteomic signature of senescence in primary human mammary epithelial cells using mass spectrometry-based proteomics and integrates it with transcriptomic data.

AKT but not MYC promotes reactive oxygen species-mediated cell death in oxidative culture

The paper shows that AKT, but not MYC, causes cell death in oxidative conditions by increasing reactive oxygen species, revealing a metabolic vulnerability in cancer cells.

NADPH consumption by L-cystine reduction creates a metabolic vulnerability upon glucose deprivation

The paper identifies L-cystine reduction as a metabolic vulnerability in cancer cells under glucose deprivation and proposes co-targeting GLUT1 and glutathione synthesis as a therapeutic strategy.

Inhibition of nucleotide synthesis promotes replicative senescence of human mammary epithelial cells

This study shows that inhibiting nucleotide synthesis induces replicative senescence in human mammary epithelial cells by blocking metabolic flux into nucleotide pathways.