Scott E. Fraser

This paper evaluates cross-talk between fluorescent proteins and NADH FLIM, identifying compatible FPs and providing a pipeline to manage cross-excitation in metabolic imaging.

The paper develops an FCS excitation scan assay to compare fluorescent reporters' brightness and photobleaching in tissue culture and zebrafish embryos, finding mNeonGreen outperforms mEGFP.

The paper identifies a cluster of negative valence neurons in the larval zebrafish pallium that respond to strongly noxious stimuli.

The paper uses live-cell imaging and mathematical modeling to study PRLR internalization dynamics and their impact on signaling in pancreatic β-cells.

The paper introduces DREAM, a method to enhance spectral visualization of autofluorescence microscopy data, improving colorfulness, sharpness, and consistency in unstained tissue samples.

The paper introduces far-red chemigenetic kinase activity biosensors enabling five-color multiplexing, 4D imaging, and super-resolution via STED microscopy.

The paper identifies and characterizes neuro-endothelial cells (NECs) in mouse brain and kidney, showing their role in regulating blood flow and immune balance through Nos1 and Cytl1.

This paper introduces a multiscale light field microscopy platform for fast 3D imaging across biological scales, demonstrating its use in whole-brain activity, calcium dynamics, and subcellular protein dynamics.

The paper shows number-selective neurons in zebrafish develop in a sequential order, with neurons for higher numbers appearing later and a decoder based on these neurons can predict visual numerosity.

The paper describes the generation of a human cone photoreceptor reporter line using CRISPR/Cas9 and demonstrates its use for live imaging of cone maturation in retinal organoids.

This study identifies Hand2's role in repressing non-cardiac cell fates through chromatin remodeling at cis-regulatory elements in zebrafish cardiac progenitors.

This paper develops a kinetic and data-driven model of pancreatic β-cell metabolism to understand its role in glucose-stimulated insulin secretion and predict therapeutic interventions.

The paper investigates the dynamics of SHR and SCR transcription factors in Arabidopsis root stem cells, showing that low transient expression, not stable levels, is critical for asymmetric division and patterning.

FRaeppli enables multispectral imaging for cell tracing and tissue analysis in zebrafish, revealing new canalicular topologies in hepatocytes.

The paper investigates the neural basis of non-symbolic number cognition in zebrafish by examining activation patterns in the pallium during changes in visual numerosity.

This study shows that inhibiting nucleotide synthesis induces replicative senescence in human mammary epithelial cells by blocking metabolic flux into nucleotide pathways.

This paper introduces a method to quantitatively analyze mRNA expression in whole vertebrate embryos with subcellular resolution, enabling both anatomical to expression and expression to anatomical queries.

The paper uses novel imaging and computational approaches to deduce how distal air exchange surfaces in the lung form through epithelial buckling and extrusion, stabilized by elastin and collagen rings.

The paper uses imaging and computational methods to propose a mechanism for the formation of the distal air exchange surfaces in the lung, involving epithelial buckling and stabilization by elastin and collagen.