Paradoxical Phenotype of Fibromyalgia Neutrophils with Elevated Baseline Inflammation but Blunted Response to Stimulation
Sahel Jahangiri Esfahani, Anahita Oveisi, Lucas Vasconcelos Lima, Sara Caxaria, Marc Parisien, Julia Vignone, Francesca Montagna, Shafaq Sikandar, Carolina B. Meloto, Jeffrey S. Mogil, Luda B. Diatchenko
The paper identifies a paradoxical inflammation state in FM neutrophils that are unresponsive to LPS, linked to NF-κB suppression, and suggests bryostatin as a potential therapeutic target.
bioRxiv · Sep 15, 2025 · PreprintMolecular Biology