Innervation and cargo-specific axonal transport impairments in FUS-ALS mice with gain and loss of function
Rebecca L. Simkin, Andrew Paul Tosolini, Alla Mikheenko, Agnieszka M Ule, Wenanlan Jin, Bernadett Kalmár, Mhoriam Ahmed, Qiuhan Lang, Franciane Lirot, Martha McLaughlin, Georgia Price, David Villarroel‐Campos, Linda Greensmith, James N. Sleigh, Thomas J. Cunningham, , Nicol Birsa
This study identifies sex-dependent motor neuron dysfunction and cargo-specific axonal transport impairments in FUS-ALS mice, linking endosomal transport defects to denervation in ALS.
bioRxiv · Jun 16, 2025 · PreprintNeuroscience