Andrew Paul Tosolini

This study shows that rescuing Schwann cells in an ALS mouse model improves myelin structure but not motor function, highlighting the complex role of Schwann cells in disease progression.

This study shows BDNF enhances axonal regeneration in human motor neurons by regulating RNA metabolism and cytoskeletal dynamics through kinase pathways.

This study generates and analyzes a novel genomically humanised SOD1A4V mouse model, revealing metabolic dysfunction through multi-omic analyses and identifying it as a potential pre-symptomatic ALS model.

This study shows that CNTF specifically slows axonal transport of signalling endosomes in both fast and slow motor neurons, highlighting selectivity in NTF regulation of transport.

This study identifies sex-dependent motor neuron dysfunction and cargo-specific axonal transport impairments in FUS-ALS mice, linking endosomal transport defects to denervation in ALS.

The paper investigates how aging affects signaling endosome transport in motor axons and finds that processivity is impaired, which is not rescued by BDNF treatment due to reduced TrkB receptor expression.

The paper investigates axonal transport dynamics of signalling endosomes and mitochondria at the Node of Ranvier in vivo, finding reduced velocity and increased pausing during transit through the NoR.

This study shows that BDNF-dependent axonal transport is selectively impaired in fast motor neurons of ALS mice, contributing to disease pathology.

This study shows that blocking the GDNF-RET signalling axis rescues axonal transport deficits in ALS models, suggesting it as a potential therapeutic target.

The paper examines axonal transport defects in two ALS mouse models, finding that TDP-43 mutations cause transport issues while FUS mutations do not.