Wenanlan Jin

The paper investigates a dual-strategy approach using a muscle-tropic AAV capsid and muscle-specific promoter to improve gene delivery efficiency and reduce off-target expression in skeletal muscle.

This study identifies sex-dependent motor neuron dysfunction and cargo-specific axonal transport impairments in FUS-ALS mice, linking endosomal transport defects to denervation in ALS.

This study shows that neonatal injury increases microglial phagocytosis of GABAergic synapses in the spinal dorsal horn, leading to long-term structural changes and altered responses to adult re-injury.