Structure of a novel α-synuclein filament fold from multiple system atrophy
N. L. Yan, Francisco Candido, Eric Tse, Arthur Alves de Melo, Stanley B. Prusiner, Daniel A. Mordes, Daniel R. Southworth, Nick A. Paras, Gregory E. Merz
The paper determines the structure of a novel α-synuclein filament fold in multiple system atrophy using cryo-EM, identifying a new filament type distinct from other synucleinopathies.
FEBS Letters · Nov 7, 2024Peer-reviewedBiophysics