Gregory E. Merz

The paper determines cryo-EM structures of low-twist α-synuclein filaments from Lewy bodies and shows they share a structural core with high-twist forms.

This study reports atomic resolution cryo-EM structures of α-synuclein fibrils from an MSA patient before and after transmission to a transgenic mouse model, showing structural adaptations while maintaining key features.

This study identifies distinct tau filament structures in FTLD-tau caused by the MAPT S305I mutation, revealing a unique 4-layer architecture and potential RNA-like polyanion binding.

The paper designs synthetic tau fibrils that mimic AD and CTE structures, showing strong seeding ability and catalytic effects in vitro and in cells.

This paper designs de novo proteins to modify nanopore complexes, creating customized structural and functional properties for enhanced sequencing applications.

The paper determines the structure of a novel α-synuclein filament fold in multiple system atrophy using cryo-EM, identifying a new filament type distinct from other synucleinopathies.

The paper uses cryo-EM to show that tau filaments in Down syndrome share the same structure as those in Alzheimer's disease.