Blood-brain barrier transport using a high-affinity, brain-selective VNAR (Variable Domain of New Antigen Receptor) antibody targeting transferrin receptor 1
Paweł Stocki, Jarosław Szary, Charlotte Laurfelt Munch Rasmussen, Mykhaylo Demydchuk, Leandra Northall, Diana Bahu Logan, Aziz Gauhar, Laura Thei, Torben Moos, Frank S. Walsh, Julia Lynn Rutkowski
The paper identifies a high-affinity VNAR antibody targeting TfR1 that efficiently crosses the BBB and delivers biotherapeutics to the brain with safety and efficacy.
bioRxiv · Jul 20, 2020 · PreprintNeuroscience