Author

Laura Thei

Stevenage Bioscience CatalystORCID 0000-0002-9472-731XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Alejo J. Nevado‐HolgadoiD· 1 shared Aziz GauhariD· 1 shared Charlotte Laurfelt Munch RasmusseniD· 1 shared Diana Bahu Logan· 1 shared Elena M. RibéiD· 1 shared Frank S. Walsh· 1 shared Jarosław Szary· 1 shared Jie QuaniD· 1 shared

Activity by Year

2017-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBioinformatics

Alejo J. Nevado‐HolgadoORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Blood-brain barrier transport using a high-affinity, brain-selective VNAR (Variable Domain of New Antigen Receptor) antibody targeting transferrin receptor 1

Paweł Stocki, Jarosław Szary, Charlotte Laurfelt Munch Rasmussen, Mykhaylo Demydchuk, Leandra Northall, Diana Bahu Logan, Aziz Gauhar, Laura Thei, Torben Moos, Frank S. Walsh, Julia Lynn Rutkowski

The paper identifies a high-affinity VNAR antibody targeting TfR1 that efficiently crosses the BBB and delivers biotherapeutics to the brain with safety and efficacy.

bioRxiv · Jul 20, 2020 · PreprintNeuroscience

Genetic and real-world clinical data, combined with empirical validation, nominate JAK-STAT signalling as a target for Alzheimer’s Disease therapeutic development

Alejo J. Nevado‐Holgado, Elena M. Ribé, Laura Thei, Laura Ines Furlong, Miguel Angel-Mayer, Jie Quan, Jill C. Richardson, Jonathan Cavanagh, Simon Lovestone

The paper combines GWAS, clinical data, and experimental models to identify JAK-STAT pathway dysregulation as a potential therapeutic target for Alzheimer’s disease.

bioRxiv · Aug 21, 2017 · PreprintBioinformatics