Torben Moos

This study investigates vascular remodeling in the substantia nigra pars reticulata of rats with chronic neurodegeneration, finding increased vascular density and tortuosity without changes in vessel wall structure.

AAV-BR1-NPC2 gene therapy reduces cholesterol deposition and neurological symptoms in NP-C2 mice by delivering NPC2 to brain endothelial cells and neurons.

The paper compares in vitro blood-brain barrier models from mice, rats, and pigs to identify species-dependent differences in barrier characteristics and TEER.

The paper identifies a high-affinity VNAR antibody targeting TfR1 that efficiently crosses the BBB and delivers biotherapeutics to the brain with safety and efficacy.

The paper identifies post-capillary venules as the site for transcytosis of therapeutic nanoparticles across the blood-brain barrier.