Induction of peri-implantation stage synthetic embryos using reprogramming paradigms in ESCs
Jan Langkabel, Arik Horne, Lorenzo Bonaguro, Tatiana Hesse, Alexej Knaus, Yannick L. Riedel, Kristian Händler, Kevin E. Bassler, Nico Reusch, Leon Harootoonovtch Yeghiazarian, Tal Pecht, Anna C. Aschenbrenner, Franziska Kaiser, Caroline Kubaczka, Joachim Ludwig Schultze, Hubert Schorle
The paper generates synthetic embryo-like structures from ESCs through transcription factor-mediated reprogramming, showing implantation and decidual tissue formation.
bioRxiv · Jan 25, 2021 · PreprintSynthetic Biology