Kevin E. Bassler

Fetal liver macrophages contribute to the hematopoietic stem cell niche by controlling granulopoiesis

The paper identifies fetal liver macrophage subpopulations and shows their role in regulating granulopoiesis and the HSC niche during embryogenesis.

Induction of peri-implantation stage synthetic embryos using reprogramming paradigms in ESCs

The paper generates synthetic embryo-like structures from ESCs through transcription factor-mediated reprogramming, showing implantation and decidual tissue formation.

Alterations of multiple alveolar macrophage states in chronic obstructive pulmonary disease

This study uses single-cell RNA-seq and computational methods to analyze macrophage states in COPD patients, revealing transcriptional changes and metabolic shifts associated with the disease.

Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells

Across 1,176,683 airway and lung cells from 22 datasets, ACE2 rises with age, in males and in smokers' multiciliated cells, and is lowest in young children.

Memory-driven computing accelerates genomic data processing

This paper demonstrates that memory-driven computing significantly accelerates NGS data processing and reduces energy consumption for RNA-seq tasks.

Diagnostic value of blood gene expression-based classifiers as exemplified for acute myeloid leukemia

The paper develops robust and accurate classifiers for AML diagnosis using blood gene expression data and machine learning across 12,029 samples from 105 studies.

FASTGenomics: An analytical ecosystem for single-cell RNA sequencing data

FASTGenomics provides a secure, flexible, and user-friendly analytical ecosystem for single-cell transcriptomics data.