Hubert Schorle

This study shows selinexor, an XPO1 inhibitor, reduces viability and induces cell-cycle arrest and apoptosis in testicular germ cell tumors by increasing nuclear p53 and p21.

This study evaluates G4-ligands in TGCTs, finding CX-5461 induces p53-dependent cell death by stabilizing G4s and disrupting RNA polymerase I transcription.

The paper investigates the fertility of male mice with one allele loss of Prm1 and Prm2, finding infertility due to sperm damage and protamine precursor retention.

This paper identifies PDE3A-SLFN12 molecular glues as a novel therapeutic target for KIT D816V-driven mast cell malignancies, showing their efficacy in killing multiple KIT D816V cell types and synergy with tyrosine kinase inhibitors.

This study shows that ACTRT2 is essential for acrosome stability in mouse sperm, with its loss causing subfertility and structural defects during spermiogenesis.

This study shows that ARPM1 is essential for acrosome biogenesis and sperm function in mice, with defects leading to subfertility and morphological abnormalities.

This study shows that protamine overexpression in somatic cells causes chromatin condensation and transcription suppression without altering DNA methylation.

The paper investigates the relationship between protamine ratios and histone acetylation levels in sperm from mice and humans, finding reduced H4ac levels associated with altered protamine ratios.

This study shows that Protamine 2 deficiency leads to Septin 12 abnormalities in sperm, affecting motility and morphology.

This study investigates the role of Cylicins in spermiogenesis and male fertility using gene-editing in mice and exome sequencing in humans, finding that Cylicin deficiency causes infertility and structural sperm abnormalities.

This study shows that Actl7b deficiency in mice causes spermatogenic arrest and cytoskeletal defects in spermatids due to mislocalization of LC8 dynein light chains.

This study shows that the cP2 domain is essential for proper sperm chromatin protamination and male fertility in mice.

This study shows that Prm1 deficiency in mice causes DNA damage, impaired PRM2 processing, and subfertility due to disrupted chromatin protamination.

This study shows TRIM71 is essential for germ cell development in mice and links TRIM71 variants to human male infertility.

The paper generates synthetic embryo-like structures from ESCs through transcription factor-mediated reprogramming, showing implantation and decidual tissue formation.

This study investigates Prm2 deficiency in mice, showing it leads to oxidative stress and DNA damage during sperm maturation, affecting fertility.