Sulfite oxidase deficiency causes persulfidation loss and H2S release
Chun-Yu Fu, Joshua B. Kohl, Filip Liebsch, Davide D’Andrea, Tamás Ditrói, Seiryo Ogata, Franziska Neuser, Max Mai, Anna‐Theresa Mellis, Emilia Kouroussis, Masanobu Morita, Titus Gehling, José Angel Santamaria‐Araujo, Sin Yuin Yeo, Heike Endepols, , Guenter Schwarz
This study shows that SOX deficiency leads to persulfidation loss and increased H2S release, with thiosulfate accumulation and metabolic rewiring in a mouse model.
Journal of Clinical Investigation · Nov 2, 2025Peer-reviewedBiochemistry